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Izzo, Borelli, et al-- Therapeutic

Posted on June 21, 2017 at 9:55 PM


Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb






Angelo A Izzo, Francesca Borrelli, Raffaele Capasso, Vincenzo Di Marzo, Raphael Mechoulam



Publication date Oct.  31, 2009

Δ9-tetrahydrocannabinol binds cannabinoid (CB1 and CB2) receptors, which are activated
by endogenous compounds (endocannabinoids) and are involved in a wide range of
physiopathological processes (eg modulation of neurotransmitter release, regulation of pain
perception, and of cardiovascular, gastrointestinal and liver functions). The well-known
psychotropic effects of Δ9-tetrahydrocannabinol, which are mediated by activation of brain
CB1 receptors, have greatly limited its clinical use.

Link to PDF:  http://www.stcm.ch/en/files/paper_izzo_tips_2009.pdf

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